When it comes to really large photos and paintings the rules seem to change a little bit when it comes to frames. You can get away with having really thick borders and much more ornate detailing without it looking ridiculous. These paintings and photographs are usually impressive in themselves so its not as hard to overshadow them. On top of that, because of their size, they easily draw attention to themselves so the frame doesn't really need to help with that.
The first 16x20 picture frame that caught my attention was made by Imperial Frames. This frame really looks nice. It is from Imperial Frames' Elite Collection so it is a lot more intricate than the rest of their products. The frame is made entirely out of wood and has a very thick border. The wood is Mahogany. I'm not sure what country the mahogany is from but it looks nice. It would be a lot easier to tell if it wasn't stained. Then again, if it wasn't stained it wouldn't hold up very long. The border is distinguished by a rope detail which appears to be some kind of brownish-gold color. This is the kind of frame that would look good with even your most precious and valued photographs and paintings.
Imperials Frames also makes a 16” x 20” frame that is a lot more minimalistic. I assume this is the goal of their Supreme Collection of frames. Its not always necessary to have a gigantic border, sometimes a small border looks a lot more tasteful. This frame is made out of walnut, which is another great looking dark colored wood. The wood has been stained to look more like oak than walnut, which actually looks pretty nice. The frame also has a gold leaf border. I think this frame would look great in just about any décor.
Frames this big don't just have to hold a single big picture. A large frame is also great for a collage of smaller photos. I discovered Large Weave Silver Collage frame which looks great. This is a true collage picture frame as opposed to a matted frame. The difference is that a true collage picture frame has multiple framed openings to display pictures in while a matted frame has a large mat you can attach pictures to anywhere. This image has fourteen places for images of varying different sizes and shapes. They seem to be split between squares, rectangles, and ovals. The frame itself is silver, but the company also offers a gold version. It looks a little bit gaudy to me but I'm sure some people will really like it.